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Scientific journal «Current problems of health care and medical statistics»
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IPH LGAT PEPTIDE COMPLEXES AS REGULATORS OF PANCREATIC GLAND FUNCTIONING AND THEIR ROLE IN INCREASING THE BIOLOGICAL RESOURCING OF LIVING SYSTEMS

E.I. Ryzhkova1,2, I.P. Pochitaeva1, E.V. Fesenko1, K.A. Ishchenko3
1. Academy of postgraduate education under FSBU FSCC of FMBA, Mosсow
2. Research Medical Centre «GERONTOLOGY», Moscow
3. Belgorod state national research University, Belgorod
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Summary:
Actuality: The pancreas plays a central role in digestion and absorption, as well as in the utilization and storage of energy substrates. As mentioned earlier, it consists of two structurally distinct but functionally integrated glandular systems, namely the exocrine and endocrine pancreas, both of which arise from outgrowths of the primitive intestine. Secretion by the exocrine pancreas is modulated by nerve and hormonal signals, especially in the form of numerous gastrointestinal peptide hormones.In connection with the above, it is considered relevant to study the properties of drugs that are able to preserve the functioning of the pancreas. Purpose: to study the possibilities of the IPH LGAT. Materials and methods: we have studied the effects of IPH LGAT on a cell and patients. German peptides IPH LGAT have all the approvals and permits for the markets of the world, such as: WADA certificate (anti-doping), MAFFA certificate (safety), ORGANIC certificate, HALAL certificate, patent protection: patent in the United States of America No. 5,405,266, patent in the European Union No. 016704471, patent in the Russian Federation No. 645608, patent in the People's Republic of China No. 30507522. The effectiveness of the use of the IPH LGAT peptide was evaluated by us before the start of the study and after 3 months. Results: After the use of the IPH LGAT peptide, the normal expression of the BMP and FGF genes, the PDX-1 gene significantly increased by 82.3%, 52.9%, respectively, which confirms the antitumor and cytostatic properties of the IPH LGAT peptide. This gives reason to conclude that the use of the IPH LGAT peptide contributes to the normal and qualitative formation of the pancreas at the gene level. The use of the IPH LGAT peptide reduces the expression of the Ki67 protein by 68.5%. These data indicate a high oncoprotective and antioxidant function of the IPH LGAT peptide in relation to the pancreas. The IPH LGAT peptide contributes to the normalization of pancreatic function in the presence of chronic pathology or not sharp deviations from the norm. Positive clinical dynamics increased the indicator of general health and general well-being by 58.2%. The use of the IPH LGAT peptide for 3 months reduces the index of the cancer marker CA 19-9 in patients with chronic pancreatitis by 57.8%. These data confirm the oncoprotective effect of the IPH LGAT peptide. After the use of the IPH LGAT peptide, the organoprotection of the pancreas increases in patients with chronic pancreatic diseases Conclusions: the use of the IPH LGAT peptide has oncoprotective and cytoprotective effects, clinically improves overall well-being and contributes to the functional stabilization of pancreatic function.
Keywords peptide complexes, pancreas, diabetes mellitus, chronic pancreatitis, hormonal balance.

Bibliographic reference:
E.I. Ryzhkova, I.P. Pochitaeva, E.V. Fesenko, K.A. Ishchenko, IPH LGAT PEPTIDE COMPLEXES AS REGULATORS OF PANCREATIC GLAND FUNCTIONING AND THEIR ROLE IN INCREASING THE BIOLOGICAL RESOURCING OF LIVING SYSTEMS // Scientific journal «Current problems of health care and medical statistics». - 2022. - №5;
URL: http://healthproblem.ru/magazines?textEn=931 (date of access: 23.11.2024).

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