Aim: To determine the prognostic value of frailty and co-morbidity for disability and mortality in the elderly. Methods: The retrospective study was conducted among outpatients aged 60 years and above. Patients with ≥ 3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The disability group was comprised of patients who failed to visit a doctor because of decreased outdoor mobility during the 3,5-year follow-up period. The outdoor high-mobility group was comprised of participants with no outdoor mobility loss. Results: 5,678 patients with a mean age of 71.0 ± 0.1 years were included in the study. The risk of outdoor mobility loss rose by 4% per year with men developing it 50% more than women (р = 0,001). The effect of frailty was of particular importance because it increased the risk of developing outdoor mobility loss by 70% (р=0,001). The risk of developing low mobility in patients with myocardial infarction was 40% higher (p=0.009) than in individuals who did not have it, and complaints of bad mood increased the risk of loss of mobility by 27% (p=0.001). The mobility loss and male gender increased the risk of mortality twice. Diabetes mellitus increases the risk of mortality by 46% (p=0.002), COPD - by 44% (p=0.005). The mortality risk for smokers is 33% higher (p=0.045) than for never-smokers. Conclusions: Frailty and co-morbidity are associated with an unfavorable prognosis for the mobility loss. and an increased risk of mortality, along with smoking, male sex, diabetes mellitus, COPD, and previous myocardial infarction. Patients with low mobility and male sex have a higher risk of mortality.