Introduction. Glaucoma is one of the most severe forms of irreversible eye disease and the second most common cause of blindness. Purpose. To analyze the clinical and economic efficiency of a screening study for the early detection of glaucoma as part of the clinical examination of the adult population and professional examinations among the population of the Lipetsk region. Material and methods. To determine the costs of conducting a screening study to detect glaucoma among the population living in the Lipetsk region, as part of the medical examination of the adult population and professional examinations, a medical and economic analysis was carried out with the initial data for 2019. Research results. In 2019, among the adult population of the Lipetsk region, 489 people were registered with the diagnosis of glaucoma for the first time in their lives, of which 68 (13.9%) cases were detected during medical examinations of the adult population and professional examinations, 421 (86.1%) cases during self-referral population to an ophthalmologist with complaints of visual impairment. According to the results of tonometry as part of the medical examination of the adult population and professional examinations of 253,567 people, 294 (0.12%) cases of increased intraocular pressure were found. When examined by an ophthalmologist in connection with the identified increased intraocular pressure, 68 new cases of glaucoma were found among the population, which accounted for 23.1% of cases from persons with increased intraocular pressure and 0.027% of cases from persons who had intraocular pressure measurement. The cost of measuring intraocular pressure in 253,567 people as part of the medical examination of the adult population amounted to 22,455,893.52 rubles, the cost of examination and diagnosis of glaucoma in 68 patients with elevated intraocular pressure amounted to 15,537.32 rubles. The proportion of false-positive tonometry results was 226 (76.9%) cases, which were additionally examined by an ophthalmologist, for which a total of 51,638.74 rubles were spent. Accordingly, the amount of expenses for an examination by an ophthalmologist increased to 67,176.06 rubles. 331,221.6 rubles were spent to identify one person with glaucoma during the medical examination of the adult population and professional examinations. The cost of screening 1 million residents of the Lipetsk region with unchanged values of the initial data will be 88,826,002 rubles. and will identify 269 new cases of glaucoma. In every third patient out of 294 people with elevated intraocular pressure referred for examination by an ophthalmologist, except for 68 new cases of glaucoma, another ophthalmopathology was detected. Conclusions. In 2019, in the Lipetsk region, based on the results of a screening study for the early detection of glaucoma as a result of tonometry of 253,567 people as part of the medical examination of the adult population, 68 (0.027%) new cases of glaucoma were detected, which cost 22,523,069.58 rubles, to identify one person with glaucoma spent 331,221.6 rubles. The cost of screening 1 million residents of the Lipetsk region will be 88,826,002 rubles. and will identify 269 new cases of glaucoma.